Concepts and methods presented in this document are consistent with those found in the International Organization for Standardization (ISO) Guide to the Expression of Uncertainty in Measurement (GUM). While the GUM provides general rules for analyzing and communicating measurement uncertainty, it does not provide detailed procedures or instructions for evaluating specific measurement processes. In addition, new methods have been developed over the past several years that enhance the methodology of the GUM. This document provides a recommended practice that clearly explains key concepts and principles for estimating and reporting measurement uncertainty. This document also includes advanced methods that extend the GUM’s guidance on estimating measurement uncertainty. The analysis methods outlined in this document provide a comprehensive approach to estimating measurement uncertainty.